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Document ID (ISN)55282
CIS number 91-202
ISSN - Serial title 0009-9309 - Clinical Toxicology
Year 1990
Convention or series no.
Author(s) Klees J.E., Lash A., Bowler R.M., Shore M., Becker C.E.
Title Neuropsychologic "impairment" in a cohort of hospital workers chronically exposed to ethylene oxide
Bibliographic information 1990, Vol.28, No.1, p.21-28. 9 ref.
Abstract Ethylene oxide is widely used to sterilise heat-sensitive materials. Acute and chronic neurogenic effects to the central and peripheral nervous system in man and animals have been described. A cross-sectional study of 25 hospital central sypply workers exposed to low levels of ethylene oxide and 24 unexposed control workers was conducted. Subjects were tested with a neuropsychological screening battery by examiners blinded to exposure status. Results were reviewed independently by 2 neuropsychologists without knowledge of exposure. Subject status was categorized as normal, "impaired," or disagreement (between the two neuropsychologists). There were more subjects concordantly judged as impaired in the exposed group than in the control group. Although limited by the cross-sectional study design and the global categorisation, these findings suggest that central nervous system dysfunction and cognitive impairment may result from chronic ethylene oxide exposure in hospital central sypply units.
Descriptors (primary) disinfection of equipment; diseases of nervous system; neuropsychic effects; hospitals; ethylene oxide
Descriptors (secondary) long-term exposure; cognitive performance
Document type D - Periodical articles
Country / State or ProvinceUSA
Subject(s) Commerce, services, offices
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the nervous system
Ethylene oxide
Health care services