| Document ID (ISN) | 55244 |
| CIS number |
91-251 |
| ISBN(s) |
0-11-885523-9 |
| Year |
1989 |
| Convention or series no. |
|
| Author(s) |
Turner R.M., Fairhurst S.
Health and Safety Executive |
| Title |
Toxicology of substances in relation to major hazards - Acrylonitrile |
| Bibliographic information |
HMSO Books, P.O. Box 276, London SW8 5DT, United Kingdom, 1989. 10p. 16 ref. Price: GBP 3.00. |
| Abstract |
This paper reviews the available toxicological data on acrylonitrile and provides a derivation for a dangerous toxic load equation. Principal effects arising from a single inhalation exposure of animals to acrylonitrile vapour are sensory irritation of eyes and nose, reddening of the skin and lung oedema. Similar signs of toxicity have been reported in humans receiving an acute exposure, with liver tenderness and jaundice reported in workers receiving sublethal exposure. Acrylonitrile is carcinogenic in animals and possibly in humans, although from data available it is not possible to describe relationships between exposures and possible effects in humans. Based on data derived from animal studies, a toxic load equation for acrylonitrile is derived and the dangerous toxic load is calculated to be 9,600ppm/min. |
| Descriptors (primary) |
United Kingdom; acrylonitrile; health hazards; major hazards; toxicology |
| Descriptors (secondary) |
literature survey; inhalation toxicity; lethal concentration 50; animal experiments |
| Document type |
F - Information notes, codes of practice, standards |
| Country / State or Province | United Kingdom |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Cyano compounds
Major hazards
Toxicology
|
