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Document ID (ISN)55097
CIS number 90-1985
Year 1989
Convention or series no. HSE Specialist Inspector Reports No.21
Author(s) Turner R.M., Fairhurst S.
Title Assessment of the toxicity of major hazard substances
Bibliographic information Health and Safety Executive, Library and Information Services, Broad Lane, Sheffield S3 7HQ, United Kingdom, May 1989. 13p. 32 ref.
Abstract This paper proposes a systematic approach for expressing the toxicological hazard to human health posed by the airborne release of a major hazard substance. The importance of using reliable toxicity data from original sources is discussed. Criteria defining the level of toxicity on which risk calculations are based are described in terms of individual risk, i.e. the likelihood of an individual receiving an exposure which will produce a specified level of toxicity, and societal risk, the frequency of a given number of deaths from a specific cause. A method is described for deriving the relationship between the atmospheric concentration of the substance and the duration of exposure for a given level of toxicity. The parameters thus deemed may be used in major hazard risk analysis.
Descriptors (primary) toxicology; chemical hazards; major hazards; hazard evaluation
Descriptors (secondary) toxic effects; report; mathematical analysis; extrapolation animal man; length of exposure; lethal concentration 50
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Major hazards
Risk evaluation