|Document ID (ISN)||54983|
|Convention or series no.
||KEMI Report 2/90
Nordic Council of Ministers
||Effects on reproduction of styrene, toluene and xylene
||Swedish National Chemicals Inspectorate, Information Secretariat, P.O. Box 1484, 171 27 Solna, Sweden, 1990. 77p. 39 ref. Price: SEK 80.00.
||Exposure to styrene is reported to cause an increase in spontaneous abortion and an increased frequency of structural chromosomal abnormalities in adults. There is currently insufficient evidence to determine the carcinogenicity of styrene, although styrene oxide is probably carcinogenic. Toluene sniffing during pregnancy is reported to cause malformation of the foetus at high concentrations. At low concentrations, toluene is a reproductive toxicant affecting the hormone balance in adults and development of the foetus. Human data suggest that exposure to solvents during pregnancy may cause congenital malformations and spontaneous abortions, although no firm conclusions on the contribution of xylene can be made.
||antifertility effects; Sweden; xylene; styrene; toxicology; toluene
||mutagenic effects; toxic effects; embryotoxic effects; styrene oxide; solvents; criteria document; spermatogenic disturbances; menstrual disorders; animal experiments; expectant mothers; carcinogenic effects; abortion
||E - Books, reports, proceedings
|Country / State or Province||Sweden|
||Toxic and dangerous substances
|Broad subject area(s)
||Antifertility and prenatal effects
Genetic factors in reaction to exposures