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CISDOC database

Document ID (ISN)54983
CIS number 90-1977
ISBN(s) 87-7303-431-2; 91-7996-222-X
Year 1990
Convention or series no. KEMI Report 2/90
Nordic Council of Ministers
Title Effects on reproduction of styrene, toluene and xylene
Bibliographic information Swedish National Chemicals Inspectorate, Information Secretariat, P.O. Box 1484, 171 27 Solna, Sweden, 1990. 77p. 39 ref. Price: SEK 80.00.
Abstract Exposure to styrene is reported to cause an increase in spontaneous abortion and an increased frequency of structural chromosomal abnormalities in adults. There is currently insufficient evidence to determine the carcinogenicity of styrene, although styrene oxide is probably carcinogenic. Toluene sniffing during pregnancy is reported to cause malformation of the foetus at high concentrations. At low concentrations, toluene is a reproductive toxicant affecting the hormone balance in adults and development of the foetus. Human data suggest that exposure to solvents during pregnancy may cause congenital malformations and spontaneous abortions, although no firm conclusions on the contribution of xylene can be made.
Descriptors (primary) antifertility effects; Sweden; xylene; styrene; toxicology; toluene
Descriptors (secondary) mutagenic effects; toxic effects; embryotoxic effects; styrene oxide; solvents; criteria document; spermatogenic disturbances; menstrual disorders; animal experiments; expectant mothers; carcinogenic effects; abortion
Document type E - Books, reports, proceedings
Country / State or ProvinceSweden
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Aromatic hydrocarbons
Genetic factors in reaction to exposures