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Document ID (ISN)54910
CIS number 90-1968
ISBN(s) 92-825-8909-9 (Eng); 92-825-8910-2 (fr)
Year 1988
Convention or series no. EUR 11659
Title Indicators for assessing exposure and biological effects of genotoxic chemicals: Consensus report
Original title Indications pour l'évaluation de l'exposition aux produits chimiques génotoxiques et de leurs effets biologiques: rapport commun [in French]
Bibliographic information Office for Official Publications of the European Communities, Grand Duchy of Luxembourg, 2985 Luxembourg, 1988. 37p. 2 ref. Price: ECU 5.00.
Abstract This document contains the report and conclusions of an international workshop held in Luxembourg in 1987. Nine types of biological monitoring methods are described: methods measuring the chemical or its metabolite in biological media; determination of mutagenic activity in biological material; cytogenetic observations on human somatic cells; detection of gene mutations in somatic cells; determination of protein or nucleic acid adducts; determination of markers of cell proliferation and transformation; determination of DNA repair; sperm assays; determination of nucleic acid damage by products in urine. It is concluded that none of the methods is able to assess exposure and estimate health risk at the individual level, although some methods are able to identify groups who are potentially at risk. Also available from the European Communities in the other official languages.
Descriptors (primary) toxic substances; biological hazards; genetic effects
Descriptors (secondary) genetic abnormalities; spermatogenic disturbances; mutagenicity tests; biological effects; carcinogenic effects; neoplasms; exposure tests; cytogenetic studies; conference; determination in urine; determination in biological matter
Document type E - Books, reports, proceedings
Country / State or ProvinceLuxembourg
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Biological hazards
Genetic factors in reaction to exposures