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Document ID (ISN)54737
CIS number 90-1639
ISBN(s) 87-7303-361 8; 91-7996-183 5
Year 1989
Convention or series no. Milj@o/rapport 1989:9
Author(s) Lagersted A., Nielsen P.A., Jensen A.A., Danielsen S., Hart J., Larsen J.C.
Title Existing chemicals: Evaluating the use of QSAR for estimating biological effects. Mutagenicity of hydrazines
Bibliographic information Nordic Council of Ministers, Store Strandstræde 18, 1255 København K., Denmark, 1989. 159p. Illus. 30 ref. Appendices.
Abstract A number of hydrazines were selected to examine the use of quantitative structure-activity relationship (QSAR) in the prediction of biological behaviour. The mutagenic activity of the selected hydrazines was tested using the same method of assay and test results were evaluated statistically. All the hydrazines tested were found to be mutagenic, with potencies varying over 2-3 orders of magnitude. Modelling procedures were used to determine which descriptors should be used to establish the QSAR. Results showed that it is possible to predict the mutagenic potential of a series of N,N-disubstituted hydrazine derivatives from their physicochemical properties by the use of a systematic test series design.
Descriptors (primary) mutagenic effects; dimethylhydrazines; hydrazines; molecular structure
Descriptors (secondary) 1,1-dimethylhydrazine; mathematical models; biological effects; mutagenicity tests
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Inorganic substances
Genetic factors in reaction to exposures