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Document ID (ISN)54505
CIS number 90-1613
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1988
Convention or series no.
Author(s) Vasilenko N.M., Kogan I.M., Zvezdaj V.I., Jašina L.N., Hipko S.E., Sventickij V.V.
Title N-cyanoethylaniline (CEA) toxicity
Original title K voprosu o toksičnosti N-cianėtilanilina (CĖA) [in Russian]
Bibliographic information Sep. 1988, No.9, p.53-54.
Abstract Physical and chemical properties. Toxicity: 30-fold intragastric administration of N-cyanoethylaniline (CEA) at 1/10 of the LD50 (0.47g/kg) to rats resulted in anaemia (reduction of oxyhaemoglobin levels and erythrocyte number) accompanied by reticulocytosis (up to 157.7%), an increase of met- and sulfhaemoglobinlevels, appearance of Heinz bodies (36.9%), a reduction of blood sulfhydryl groups, leucocytosis and a reduction in the relative weight of the spleen. CEA exposure may cause signs of liver functional disturbances. The threshold of acute toxicity for CEA is 9mg/m3 (criterion of methaemoglobin formation). A MAC of 0.1mg/m3 for CEA (aerosol) in workplace air (with the notation "skin", hazard class 2) is recommended. Precautions: protection of respiratory tract, gastrointestinal tract and skin from contact with CEA.
Descriptors (primary) threshold limit values; toxicity evaluation; N-cyanoethylaniline
Descriptors (secondary) toxic effects; aromatic amines; lethal dose 50; animal experiments; permissible levels
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Cyano compounds
Occupational exposure limits