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Document ID (ISN)54231
CIS number 90-1287
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Greenberg H.L., Ott M.G., Shore R.E.
Title Men assigned to ethylene oxide production or other ethylene oxide related chemical manufacturing: A mortality study
Bibliographic information Apr. 1990, Vol.47, No.4, p.221-230. 44 ref.
Abstract Retrospective cohort study on 2174 men employed between 1940 and 1978 by a large chemical company, who had been assigned to a chemical production department that used or produced ethylene oxide (EO). Comparisons were made with the general US population, the regional population, and with a group of 26,965 unexposed men from the same plants. Comparisons with general US deaths rates showed fewer deaths than expected in the EO group due to all causes and for total cancers. Seven deaths each due to leukaemia and pancreatic cancer were observed with 3.0 and 4.1 deaths expected. The relative risk of death due to each disease was strongly related to duration of assignments to that department. When men who worked in the chlorohydrin department were excluded, there was no evidence for an association of exposure to EO with pancreatic cancer or leukaemia. Together with the failure to show independent EO associations, the chlorohydrin department results suggest that leukaemia and pancreatic cancer may have been associated primarily with production of ethylene chlorohydrin or propylene chlorohydrin, or both.
Descriptors (primary) chemical industry; mortality; carcinogenic effects; synergism; ethylene oxide
Descriptors (secondary) 2-chloroethanol; comparative study; long-term study; hours of work
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Ethylene oxide