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Document ID (ISN)54148
CIS number 90-1283
ISSN - Serial title 0029-0440 - Niigata Medical Journal
Year 1989
Convention or series no.
Author(s) Sasagawa M.
Title Agricultural chemicals in cholesterol gallstones - with special reference to an epidemiological study on cancer of the biliary tract
Original title Tanno koresterōru kessekichū no zanryū nōyaku bunseki - tokuni tandōgan no ekigakuteki shiten kara [in Japanese]
Bibliographic information Feb. 1989, Vol.103, No. 2, p.104-111. Illus. 22 ref.
Abstract Niigata prefecture (Japan) has a very high mortality rate from biliary tract cancer. There is a correlation between the standardised mortality ratio (SMR) for biliary tract cancer and the amount of certain agricultural chemicals consumed. Agricultural chemicals were detected in cholesterol gallstones of 99 patients, including 11 patients with gallbladder cancer. DLD, pp'-DDT, β-BHC and PCB were detected in the gallstones, even though the epidemiological study showed no positive correlation between them and the SMR for biliary tract cancer. MCPA, MCPB, CNP and simetryn, which did show significant correlations with the SMR, were not detected. Further investigation of the biliary excretion of the metabolites of these chemicals is indicated.
Descriptors (primary) Japan; biliary tract diseases; neoplasms; pesticides; gallbladder diseases; mortality
Descriptors (secondary) epidemiologic study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Gastrointestinal diseases
Agricultural chemicals