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Document ID (ISN)53989
CIS number 90-940
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Kiesselbach N., Ulm K., Lange H.J., Korallus U.
Title A multicentre mortality study of workers exposed to ethylene oxide
Bibliographic information Mar. 1990, Vol.47, No.3, p.182-188. Illus. 22 ref.
Abstract The cohort consisted of 2,658 men from 8 chemical plants of 6 chemical companies in the Federal Republic of Germany who had been exposed to ethylene oxide for at least 1 year between 1928 and 1981. By the closing date of the study (31 Dec. 1982) 268 had died, 68 from malignant neoplasms. For 63 employees who had left the plant (2.4%) the vital status remained unknown. The standardised mortality ratio (SMR) for all causes of death was 0.87 and for all malignancies 0.97 compared with national rates. When local state rates were used the SMRs were slightly lower. Two deaths from leukaemia were observed compared with 2.35 expected. SMRs for carcinoma of the oesophagus (2.0) and carcinoma of the stomach (1.38) were raised but not significantly. In 1 plant an internal "control group" was selected matched for age, sex, and date of entry into the factory and compared with the exposed group. In both groups a "healthy worker effect" was observed. The total mortality and mortality from malignant neoplasms was higher in the exposed than in the control group; the differences were not statistically significant.
Descriptors (primary) chemical industry; carcinogenic effects; ethylene oxide; mortality
Descriptors (secondary) Germany (Federal Republic of); cancer; comparative study; frequency rates; long-term study
Document type D - Periodical articles
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Ethylene oxide