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CISDOC database

Document ID (ISN)53976
CIS number 90-922
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1990
Convention or series no.
Author(s) Yardley-Jones A., Anderson D., Lovell D.P., Jenkinson P.C.
Title Analysis of chromosomal aberrations in workers exposed to low level benzene
Bibliographic information Jan. 1990, Vol.47, No.1, p.48-51. 7 ref.
Abstract Metaphase chromosome preparations were analysed as part of a larger study from a population occupationally exposed to benzene and compared with a control group. The incidence of chromosomal aberrations in the exposed group was slightly increased compared with the control group. This increase was of borderline significance in parametric statistical tests but was significant using Fisher's exact test. No lifestyle factors had any consistent effect on the incidence of chromosome aberrations, although there was a small reduction in gaps with increasing cigarette smoking. Older individuals had a higher incidence of chromosome exchanges and "other" aberrations. Individuals who reported a recent viral illness had a higher incidence of aberrations, particularly gaps. The increased incidence of aberrations seen in the group exposed to benzene may result from a history of exposure to benzene. Nevertheless, other explanations such as sampling, interindividual variability, and unintentional bias in the selection of the 2 groups cannot be excluded.
Descriptors (primary) benzene; chromosome changes; genetic effects
Descriptors (secondary) virus diseases; comparative study; analysis of chromosome aberrations; age-linked differences
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Aromatic hydrocarbons
Antifertility and prenatal effects
Genetic factors in reaction to exposures
Bacterial and parasitic diseases
Viral diseases (other than aids)