|Document ID (ISN)||53976|
|ISSN - Serial title
||0007-1072 - British Journal of Industrial Medicine
|Convention or series no.
||Yardley-Jones A., Anderson D., Lovell D.P., Jenkinson P.C.
||Analysis of chromosomal aberrations in workers exposed to low level benzene
||Jan. 1990, Vol.47, No.1, p.48-51. 7 ref.
||Metaphase chromosome preparations were analysed as part of a larger study from a population occupationally exposed to benzene and compared with a control group. The incidence of chromosomal aberrations in the exposed group was slightly increased compared with the control group. This increase was of borderline significance in parametric statistical tests but was significant using Fisher's exact test. No lifestyle factors had any consistent effect on the incidence of chromosome aberrations, although there was a small reduction in gaps with increasing cigarette smoking. Older individuals had a higher incidence of chromosome exchanges and "other" aberrations. Individuals who reported a recent viral illness had a higher incidence of aberrations, particularly gaps. The increased incidence of aberrations seen in the group exposed to benzene may result from a history of exposure to benzene. Nevertheless, other explanations such as sampling, interindividual variability, and unintentional bias in the selection of the 2 groups cannot be excluded.
||benzene; chromosome changes; genetic effects
||virus diseases; comparative study; analysis of chromosome aberrations; age-linked differences
||D - Periodical articles
|Broad subject area(s)
Antifertility and prenatal effects
Genetic factors in reaction to exposures
Bacterial and parasitic diseases
Viral diseases (other than aids)