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CISDOC database
Document ID (ISN) | 53935 |
CIS number |
90-830 |
ISSN - Serial title |
0105-1873 - Contact Dermatitis |
Year |
1989 |
Convention or series no. |
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Author(s) |
Larmi E., Lahti A., Hannuksela M. |
Title |
Immediate contact reactions to benzoic acid and the sodium salt of pyrrolidone carboxylic acid - Comparison of various skin sites |
Bibliographic information |
Jan. 1989, Vol.20, No.1, p.38-40. Illus. 6 ref. |
Abstract |
Benzoic acid (BA) and the sodium salt of pyrrolidone carboxylic acid (NaPCA) were tested in 13 healthy persons to obtain information about the irritant properties of NaPCA and the reactivity of various skin sites. BA at 16, 8, and 4mM pet., and NaPCA at 50, 25, 12.5, and 6.25% in water, were applied to the forehead, cheek, neck and upper back. Erythema reactions were observed visually, and the changes in the skin blood flow were monitored with a laser-Doppler flowmeter. BA at 16mM increased blood flow on the cheek of 12 test subjects, and on the neck, forehead and upper back of 6 subjects, but 8 and 4mM BA elicited reactions only on the cheek. NaPCA caused reactions of the upper back of 3 test subjects only, but not on other test sites. |
Descriptors (primary) |
benzoic acid; sodium pyrrolidonecarboxylate; allergy tests; skin allergies; urticaria; irritants |
Descriptors (secondary) |
allergens; dangerous substances |
Document type |
D - Periodical articles |
Subject(s) |
Toxic and dangerous substances
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Broad subject area(s) |
Occupational medicine, epidemiology
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Browse category(ies) |
Allergies Skin diseases
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