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CISDOC database

Document ID (ISN)53788
CIS number 90-804
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Thrasher J.D., Madison R., Broughton A., Gard Z.
Title Building-related illness and antibodies to albumin conjugates of formaldehyde, toluene diisocyanate, and trimellitic anhydride
Bibliographic information 1989, Vol.15, No.2, p.187-195. Bibl.
Abstract A case of building-related health complaints was investigated with respect to the relationship among frequency of symptoms, antibodies to albumin conjugates of formaldehyde (HCHO), toluene diisocyanate (TDI), and trimellitic anhydride (TMA), and volatile organic chemicals (VOCs). The indoor air concentrations of VOCs, HCHO, TDI and TMA did not exceed Fed-OSHA and ACGIH permissible standards. However, HCHO concentrations ranged between 0.05 and 0.08ppm. The reported symptoms were multiple, involving the eyes, nose, sinuses, throat, lungs, skeletomuscular system and central nervous system. Anti-HCHO, TDI, and TMA isotypes were found in 12 of 14 full-time employees and were nondetectable in one part-time employee. The data suggest that a synergistic immunological response to airborne chemicals may be occurring in these subjects. In conclusion, immunological monitoring of affected individuals where chemicals are suspected may prove to be useful in future investigations of building-related illness.
Descriptors (primary) formaldehyde; organic compounds; tolylene diisocyanate; sick building syndrome; volatile substances; trimellitic anhydride; immunobiological changes; symptoms
Descriptors (secondary) permissible levels; exposure tests; personnel monitoring
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) General safety, health and conditions of work
Browse category(ies) Sick building syndrome
Isocyanates
Cyano compounds
Aldehydes