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CISDOC database

Document ID (ISN)53782
CIS number 90-898
ISSN - Serial title 0098-4108 - Journal of Toxicology and Environmental Health
Year 1989
Convention or series no.
Author(s) Benigni R., Andreoli C., Giuliani A.
Title Interrelationships among carcinogenicity, mutagenicity, acute toxicity, and chemical structure in a genotoxicity data base
Bibliographic information May 1989, Vol.27, No.1, p.1-20. Bibl.
Abstract Computerised data analysis of the data base generated by the International Program for the Evaluation of Short-Term Tests for Carcinogens (IPESTTC). With the use of statistical regression methods, three main associations were evidenced: (1) the well-known correlation between carcinogenicity and mutagenicity; (2) a correlation between mutagenicity and toxicity (LD50 ip in mice); and (3) a correlation between toxicity and a recently introduced estimator of the free energy due to the binding of molecules to biological receptors. No simple relationship between mutagenicity or carcinogenicity and chemical descriptors was found. To overcome this problem, a new pattern recognition method (REPAD) was used. This approach generated a classification rule able to correctly assign about 80% of carcinogens or mutagens.
Descriptors (primary) mutagens; genetic effects; lethal dose 50; carcinogens
Descriptors (secondary) computer analysis; computerized data bases
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects