| Document ID (ISN) | 53745 |
| CIS number |
90-893 |
| ISSN - Serial title |
0271-3586 - American Journal of Industrial Medicine |
| Year |
1988 |
| Convention or series no. |
|
| Author(s) |
Ward E., Halperin W., Thun M., Grossman H.B., Fink B., Kross L., Osorio A.M., Schulte P. |
| Title |
Bladder tumors in two young males occupationally exposed to MBOCA |
| Bibliographic information |
1988, Vol.14, No.3, p.267-272. Illus. 19 ref. |
| Abstract |
MBOCA (4,4' methylenebis (2-chloroaniline)) is a structural analogue of benzidine and is carcinogenic in mice, rats, and dogs. MBOCA has not yet been demonstrated to be carcinogenic in humans and is not regulated as an occupational carcinogen in the United States. Two noninvasive papillary tumours of the bladder are reported, identified in a screening study of 540 workers exposed to MBOCA during its production at a Michigan chemical plant from 1968 to 1979. Both tumours occurred in men under 30yrs old who had never smoked. Although the prevalence of grade 1-2 tumours among asymptomatic males in this age group is unknown, the incidence of clinically apparent tumours on U.S. males aged 25-29 is only 1 per 100,000 per year. The detection of the 2 tumours in young, non-smoking males is consistent with the hypothesis that MBOCA induces bladder neoplasms in humans. |
| Descriptors (primary) |
carcinogens; chemical industry; carcinogenic effects; bladder tumour; exposure evaluation; methylenebis(2-chloroaniline) |
| Descriptors (secondary) |
cystoscopy; dangerous substances; USA; neoplasms; long-term exposure; medical examinations; epidemiologic study |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Exposure evaluation
Diseases of the kidney and the urinary system
|
