|Document ID (ISN)||53724|
|ISSN - Serial title
||0003-9896 - Archives of Environmental Health
|Convention or series no.
||Osterloh J.D., Wang R., Schneider F., Maddy K.
||Biological monitoring of dichloropropene: Air concentrations, urinary metabolite, and renal enzyme excretion
||July-Aug. 1989, Vol.44, No.4, p.207-213. Illus. 28 ref.
||Fifteen applicators of dichloropropene (DCP) were studied for personal air exposure to DCP, excretion of the metabolite of DCP (3CNAC), and excretion of the renal tubular enzyme, N-acetyl glucosaminidase (NAG). Each was studied for four 6-8h consecutive intervals following baseline determination of 3CNAC and NAG excretion. In accord with pilot data, 24-h urinary excretion of 3CNAC (mg) correlated well with exposure product for DCP. A more precise correlation of the air exposure product with urinary excretion of 3CNAC was discerned by using the morning urine after the previous day of exposure. Four workers had clinically elevated activity of NAG in all of their urine collections after baseline. Nine workers showed greater than 25% increases in NAG excretion when compared to baseline. Dichloropropene air exposure products of >700mg.min/m3 or excretion of >1.5mg 3CNAC/d distinguished abnormally high daily excretion of NAG. These data demonstrate a firm positive relationship between air exposure and internal exposure, and a possible subclinical nephrotoxic effect in DCP workers.
||agricultural chemicals; exposure tests; dichloropropene; metabolic process
||nephrotoxic effects; fumigants
||D - Periodical articles
||Agriculture, fishing, animal husbandry
|Broad subject area(s)