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CISDOC database

Document ID (ISN)53724
CIS number 90-930
ISSN - Serial title 0003-9896 - Archives of Environmental Health
Year 1989
Convention or series no.
Author(s) Osterloh J.D., Wang R., Schneider F., Maddy K.
Title Biological monitoring of dichloropropene: Air concentrations, urinary metabolite, and renal enzyme excretion
Bibliographic information July-Aug. 1989, Vol.44, No.4, p.207-213. Illus. 28 ref.
Abstract Fifteen applicators of dichloropropene (DCP) were studied for personal air exposure to DCP, excretion of the metabolite of DCP (3CNAC), and excretion of the renal tubular enzyme, N-acetyl glucosaminidase (NAG). Each was studied for four 6-8h consecutive intervals following baseline determination of 3CNAC and NAG excretion. In accord with pilot data, 24-h urinary excretion of 3CNAC (mg) correlated well with exposure product for DCP. A more precise correlation of the air exposure product with urinary excretion of 3CNAC was discerned by using the morning urine after the previous day of exposure. Four workers had clinically elevated activity of NAG in all of their urine collections after baseline. Nine workers showed greater than 25% increases in NAG excretion when compared to baseline. Dichloropropene air exposure products of >700mg.min/m3 or excretion of >1.5mg 3CNAC/d distinguished abnormally high daily excretion of NAG. These data demonstrate a firm positive relationship between air exposure and internal exposure, and a possible subclinical nephrotoxic effect in DCP workers.
Descriptors (primary) agricultural chemicals; exposure tests; dichloropropene; metabolic process
Descriptors (secondary) nephrotoxic effects; fumigants
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Biological monitoring
Halogenated hydrocarbons
Agricultural chemicals