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Document ID (ISN)53687
CIS number 90-534
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 1989
Convention or series no.
Author(s) Huynh C.K., Vu Duc T., Savolainen H.
Title Controlled dynamic generation of standard 1,6-hexamethylene diisocyanate aerosols
Bibliographic information 1989, Vol.33, No.4, p.573-581. Illus. 9 ref.
Abstract A procedure for the dynamic generation of 1,6-hexamethylene diisocyanate (HDI) aerosol atmospheres of 70µg m-3 to 1.75mg m-3 based on the precise control of the evaporation of pure liquid HDI and subsequent dilution with air, was developed. The apparatus consisted of a home-made glass nebuliser coupled with a separation stage to exclude non-respirable droplets (>10µm). The aerosol concentrations were achieved by passing air through the nebuliser at 1.5-4.5 L.min-1 to generate dynamically 0.01-0.25ppm of diisocyanate in an experimental chamber of 8.55m3. The distribution of the liquid aerosol was established with an optical counter and the diisocyanate concentration was determined from samples collected in impingers by a high-pressure liquid chromatographic method. The atmospheres generated were suitable for the evaluation both of sampling procedures full scale, and of analytical methods: at 140µg m-3 (0.02ppm) they remained stable for 15min provocation tests in clinical asthma, as verified by breath-zone sampling of exposed patients.
Descriptors (primary) hexamethylene diisocyanate; evaporation; aerosols; liquids
Descriptors (secondary) impingement sampling; high-pressure liquid chromatography; description of technique
Document type D - Periodical articles
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Isocyanates
Cyano compounds