|Document ID (ISN)||53687|
|ISSN - Serial title
||0003-4878 - Annals of Occupational Hygiene
|Convention or series no.
||Huynh C.K., Vu Duc T., Savolainen H.
||Controlled dynamic generation of standard 1,6-hexamethylene diisocyanate aerosols
||1989, Vol.33, No.4, p.573-581. Illus. 9 ref.
||A procedure for the dynamic generation of 1,6-hexamethylene diisocyanate (HDI) aerosol atmospheres of 70µg m-3 to 1.75mg m-3 based on the precise control of the evaporation of pure liquid HDI and subsequent dilution with air, was developed. The apparatus consisted of a home-made glass nebuliser coupled with a separation stage to exclude non-respirable droplets (>10µm). The aerosol concentrations were achieved by passing air through the nebuliser at 1.5-4.5 L.min-1 to generate dynamically 0.01-0.25ppm of diisocyanate in an experimental chamber of 8.55m3. The distribution of the liquid aerosol was established with an optical counter and the diisocyanate concentration was determined from samples collected in impingers by a high-pressure liquid chromatographic method. The atmospheres generated were suitable for the evaluation both of sampling procedures full scale, and of analytical methods: at 140µg m-3 (0.02ppm) they remained stable for 15min provocation tests in clinical asthma, as verified by breath-zone sampling of exposed patients.
||hexamethylene diisocyanate; evaporation; aerosols; liquids
||impingement sampling; high-pressure liquid chromatography; description of technique
||D - Periodical articles
||Dust, aerosols and related diseases
|Broad subject area(s)