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CISDOC database

Document ID (ISN)53682
CIS number 90-594
Year 1989
Convention or series no. DHHS (NIOSH) Publication No.90-101
Title Current Intelligence Bulletin No.53 - Toluene diisocyanate (TDI) and toluenediamine (TDA): Evidence of carcinogenicity
Bibliographic information U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226, USA, 1989. 20p. Bibl.
Abstract Experimental studies have demonstrated that TDI and TDA (a hydrolysis product of TDI) are carcinogens. The test results meet both OSHA and NIOSH criteria for classifying a substance as a potential occupational carcinogen. NIOSH therefore recommends that all isomers of TDI and TDA be considered as potential carcinogens and that exposures be limited to the lowest feasible concentrations.
Descriptors (primary) carcinogens; tolylene diisocyanate; diaminotoluenes; USA
Descriptors (secondary) mutagenic effects; animal experiments; hazard evaluation; 2,4-diaminotoluene
Document type F - Information notes, codes of practice, standards
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Genetic factors in reaction to exposures
Isocyanates
Cyano compounds
Aromatic amines