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Document ID (ISN)53449
CIS number 90-564
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Gardner M.J., Coggon D., Pannett B., Harris E.C.
Title Workers exposed to ethylene oxide: a follow up study
Bibliographic information Dec. 1989, Vol.46, No.12, p.860-865. 10 ref.
Abstract A cohort study has been carried out of 2876 men and women employees from four companies that have produced or used ethylene oxide since the 1950s and from eight hospitals which have had ethylene oxide sterilising units since the 1960s. Industrial hygiene data were not available before 1977, but since then time weighted average exposures have been less than 5ppm in almost all jobs and less than 1ppm in many. Past exposures were probably somewhat higher. In contrast to some previous studies, no clear excess of leukaemia (three deaths observed, 2.09 expected) and no increase in stomach cancer (five deaths observed, 5.95 expected) were found. This discrepancy with earlier reports may be due in part to differences in levels of exposure. Total cancer mortality was similar to that expected from national and local death rates. Some specific cancers showed small excesses but their relevance to ethylene oxide exposure is doubtful. Again, contrary to some earlier reports, no excess of cardiovascular disease was found.
Descriptors (primary) chemical industry; morbidity; carcinogenic effects; hospitals; ethylene oxide
Descriptors (secondary) mortality; comparative study; long-term study; exposure evaluation
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Ethylene oxide
Health care services