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Document ID (ISN)53229
CIS number 90-222
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1988
Convention or series no.
Author(s) Buslovič S. Ju., Krysanova A.I., Soroka L.I., Kravčenok S.N., Vojnova I.V., Mikluš T.A.
Title Impact of different routes of chlorinated phenoxy acid administration on the microsomal oxidation processes in the liver
Original title Vlijanie različnyh putej vvedenija hlorproizvodnyh fenoksikislot na processy mikrosomal'nogo okislenija v pečeni [in Russian]
Bibliographic information May 1988, No.5, p.89-91. 8 ref.
Abstract Study of the liver detoxification system and the corresponding metabolic processes with respect to different routes of administration (intragastric and percutanous) of herbicides (butyl ether of 2,4-dichlorophenoxyacetic acid (2,4-DA) and sodium salt of 2,4-dichlorophenoxypropionic acid (2,2-DPA)). Intragastric administration of the chlorophenoxy compounds resulted in significant activation of enzymatic microsomal oxidation systems. Parenterally administered preparations had no significant inducing effects. This shows the necessity of differentiating between detoxication mechanisms associated with different routes of exposure to harmful substances.
Descriptors (primary) herbicides; occupational hygiene; routes of entry; liver; metabolic detoxication
Descriptors (secondary) exposure evaluation; metabolic studies; animal experiments
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals