Document ID (ISN) | 53229 |
CIS number |
90-222 |
ISSN - Serial title |
0016-9900 - Gigiena i sanitarija |
Year |
1988 |
Convention or series no. |
|
Author(s) |
Buslovič S. Ju., Krysanova A.I., Soroka L.I., Kravčenok S.N., Vojnova I.V., Mikluš T.A. |
Title |
Impact of different routes of chlorinated phenoxy acid administration on the microsomal oxidation processes in the liver |
Original title |
Vlijanie različnyh putej vvedenija hlorproizvodnyh fenoksikislot na processy mikrosomal'nogo okislenija v pečeni [in Russian] |
Bibliographic information |
May 1988, No.5, p.89-91. 8 ref. |
Abstract |
Study of the liver detoxification system and the corresponding metabolic processes with respect to different routes of administration (intragastric and percutanous) of herbicides (butyl ether of 2,4-dichlorophenoxyacetic acid (2,4-DA) and sodium salt of 2,4-dichlorophenoxypropionic acid (2,2-DPA)). Intragastric administration of the chlorophenoxy compounds resulted in significant activation of enzymatic microsomal oxidation systems. Parenterally administered preparations had no significant inducing effects. This shows the necessity of differentiating between detoxication mechanisms associated with different routes of exposure to harmful substances. |
Descriptors (primary) |
herbicides; occupational hygiene; routes of entry; liver; metabolic detoxication |
Descriptors (secondary) |
exposure evaluation; metabolic studies; animal experiments |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
|
Broad subject area(s) |
Chemical safety
|
Browse category(ies) |
Agricultural chemicals
|