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Document ID (ISN)53196
CIS number 90-216
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1989
Convention or series no.
Author(s) Taskinen H., Antilla A., Lindbohm M.L., Sallmén M., Hemminki K.
Title Spontaneous abortions and congenital malformations among the wives of men occupationally exposed to organic solvents
Bibliographic information Oct. 1989, Vol.15, No.5, p.345-352. Illus. 19 ref.
Abstract A case-referent study nested in a cohort monitored biologically for exposure to six organic solvents (styrene, toluene, xylene, tetrachloroethylene, trichloroethylene, and 1,1,1-trichloroethane) was conducted to investigate the effects of paternal exposure on pregnancy outcome. The pregnancies were identified from medical registers. The exposures of the men during the spermatogenesis preceding the pregnancies and of the women during the first trimester of the pregnancies were obtained with questionnaires, and the available biological monitoring measurements were used in the exposure assesment. Factors which significantly increased the odds ratio of spontaneous abortion were paternal exposure to organic solvents in general, high/frequent exposure to toluene or miscellaneous organic solvents (including thinners), and maternal heavy lifting. No significant association between paternal or maternal exposure and congenital malformations was found, but because of the few cases no firm conclusions can be drawn.
Descriptors (primary) organic solvents; expectant mothers; genetic effects; abortion
Descriptors (secondary) 1,1,1-trichloroethane; trichloroethylene; tetrachloroethylene; toluene; exposure tests; xylene; questionnaire survey; long-term study; styrene
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the reproductive system
Genetic factors in reaction to exposures
Antifertility and prenatal effects