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CISDOC database

Document ID (ISN)52926
CIS number 89-1984
Year 1988
Convention or series no. ECETOC Technical Report No.31
Title The mutagenicity and carcinogenicity of vinyl chloride: a historical review and assessment
Bibliographic information European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, B. 63, 1050 Bruxelles, Belgium, 28 July 1988. 147p. Illus. Bibl.
Abstract It is well established that prolonged exposure to high concentrations of vinyl chloride can cause angiosarcoma of the liver, but there is no convincing evidence that it causes cancer at other sites, or that it has teratogenic or heritable mutagenic effects in man. Various non-carcinogenic effects of chronic occupational exposure, collectively called "vinyl chloride disease" have not been reported in workers exposed to vinyl chloride after permissible levels were lowered to a few ppm in the early 1970s. Compliance with limits on industrial emissions and residual monomer in plastic products has reduced general exposure to negligible levels.
Descriptors (primary) mutagenic effects; vinyl chloride; carcinogenic effects; hazard evaluation; biological effects; toxicology
Descriptors (secondary) literature survey; animal experiments; epidemiologic study; report
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Genetic factors in reaction to exposures
Risk evaluation
Antifertility and prenatal effects