|Document ID (ISN)||52926|
|Convention or series no.
||ECETOC Technical Report No.31
||The mutagenicity and carcinogenicity of vinyl chloride: a historical review and assessment
||European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, B. 63, 1050 Bruxelles, Belgium, 28 July 1988. 147p. Illus. Bibl.
||It is well established that prolonged exposure to high concentrations of vinyl chloride can cause angiosarcoma of the liver, but there is no convincing evidence that it causes cancer at other sites, or that it has teratogenic or heritable mutagenic effects in man. Various non-carcinogenic effects of chronic occupational exposure, collectively called "vinyl chloride disease" have not been reported in workers exposed to vinyl chloride after permissible levels were lowered to a few ppm in the early 1970s. Compliance with limits on industrial emissions and residual monomer in plastic products has reduced general exposure to negligible levels.
||mutagenic effects; vinyl chloride; carcinogenic effects; hazard evaluation; biological effects; toxicology
||literature survey; animal experiments; epidemiologic study; report
||E - Books, reports, proceedings
||Toxic and dangerous substances
|Broad subject area(s)
Genetic factors in reaction to exposures
Antifertility and prenatal effects