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CISDOC database

Document ID (ISN)52616
CIS number 89-1625
Year 1988
Convention or series no. ECETOC Monograph No.11
Title Eye irritation testing
Bibliographic information European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, B.63, 1050 Bruxelles, Belgium, June 1988. 65p. Illus. Bibl.
Abstract This report discusses the Draize rabbit eye test and alternatives. The test may overestimate the ocular hazard to man in some cases, but appears to be effective in demonstrating the absence of ocular hazards. More data on human eye irritation must be collected if the correlation is to be improved. Alternative tests are insufficiently validated to replace the rabbit model, but some may be useful for initial screening. The various present systems for classifying ocular hazards are so different that a given chemical can be classified in several different ways on the basis of the same experimental data. Recommendations: modification of the test to minimise the number of animals used and the discomfort to which they are subjected; harmonisation of classification systems.
Descriptors (primary) dangerous substances; eye irritation; animal experiments; caustic substances; hazard evaluation; harmful substances
Descriptors (secondary) report
Document type E - Books, reports, proceedings
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Alkaline materials
Risk evaluation