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Document ID (ISN)52423
CIS number 89-1580
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1987
Convention or series no.
Author(s) Šmidt P., Ivanov N.G.
Title Methodological approaches to the assessment of short-term exposure to industrial chemicals with hepatotoxic properties
Original title Metodočeskie podhody k ocenke gepatotropnogo dejstvija promyšlennyh veščestv pri kratkosročnom vozdejstvii [in Russian]
Bibliographic information Dec. 1987, No.12, p.33-36. Illus. 8 ref.
Abstract Animal experiments carried out to investigate changes in liver function as a result of short-term exposure to known hepatotoxic chemicals (carbon tetrachloride, allyl alcohol, styrene) and to new industrial chemical compounds (diallyl phthalate, diaminodiphenylmethane etc.) showed the need for standardisation of experimental conditions for determination of the threshold of acute action of toxic chemicals on liver function for the purposes of hygienic standardisation. A set of compulsory and additional tests for detecting hepatotoxic effects of occupational poisons under conditions of short-term exposure is recommended.
Descriptors (primary) methylenedianiline; allyl alcohol; hepatotoxic effects; standardization; styrene; diallyl phthalate; carbon tetrachloride
Descriptors (secondary) chloroform; 1,1,2,2-tetrachloroethane; diallyl isophthalate; short-term exposure; toxic substances; animal experiments; metabolic disturbances
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Alcohols
Aromatic amines
Halogenated hydrocarbons
Aromatic hydrocarbons
Esters and salts