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CISDOC database

Document ID (ISN)52179
CIS number 89-1298
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1988
Convention or series no.
Author(s) Chen J.L., Fayerweather W.E., Pell S.
Title Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile
Bibliographic information Oct. 1988, Vol.30, No.10, p.813-818. 29 ref.
Abstract This study was to determine whether exposure to dimethylformamide (DMF) and acrylonitrile (ACN), separately or in combination, was associated with increased cancer incidence. Workers exposed to DMF and/or ACN were observed from 1956 through 1984 for cancer incidence. The workers exposed to DMF but not ACN showed significant excesses in incidence for buccal cavity and pharynx cancer and malignant melanoma. A significant excess of prostate cancer incidence was observed among wokers exposed to DMF and ACN. No dose-response relationships were observed between DMF or ACN exposure and cancer incidence. The significant excesses in cancer incidence among employees exposed to DMF and/or ACN could be due to statistical chance or other factors, such as tobacco and alcohol consumption. Further studies are warranted.
Descriptors (primary) chemical industry; acrylonitrile; neoplasms; synergism; dimethylformamide
Descriptors (secondary) melanoma; USA; laryngeal cancer; epidemiologic study; prostatic cancer; hazard evaluation; mouth diseases
Document type D - Periodical articles
Subject(s) Chemicals, plastics and rubber
Broad subject area(s) Chemical safety
Browse category(ies) Chemical industry
Cyano compounds
Amides