| Document ID (ISN) | 52139 |
| CIS number |
89-1285 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1988 |
| Convention or series no. |
|
| Author(s) |
Åesson B., Skerfving S., Mattiasson L. |
| Title |
Experimental study on the metabolism of triethylamine in man |
| Bibliographic information |
Apr. 1988, Vol.45, No.4, p.262-268. Illus. 14 ref. |
| Abstract |
Five healthy volunteers were exposed by inhalation to triethylamine (TEA; 4 or 8h at about 10, 20, 35, and 50mg/m3), a compound widely used as a curing agent in polyurethane systems. Analysis of plasma and urine showed that an average of 24% of the TEA was biotransformed into triethylamine-N-oxide (TEAO) but with a wide interindividual variation (15-36%). The TEA and TEAO were quantitatively eliminated in the urine. The plasma and urinary concentrations of TEA and TEAO decreased rapidly after the end of exposure (averge half time of TEA was 3.2h). There was excellent association between air levels of TEA and the urinary concentrations in samples obtained within 2h of the end of exposure. Thus the urinary level of TEA taken in this period is useful as a biological monitoring of exposure. An air concentration of 10mg/m3 corresponds to an average urinary concentration of about 40mmol/mol creatinine (at sedentary work). |
| Descriptors (primary) |
triethylamine; inhalation tests; hazard evaluation |
| Descriptors (secondary) |
conditions of exposure; human experiments; determination of concentration; determination in blood; determination in urine; length of exposure |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Risk evaluation
Aliphatic amines
|
