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CISDOC database

Document ID (ISN)52026
CIS number 89-1280
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1988
Convention or series no.
Author(s) Musk A.W., Peters J.M., Wegman D.H.
Title Isocyanates and respiratory disease: Current status
Bibliographic information 1988, Vol.13, No.3, p.331-349. 114 ref.
Abstract This paper reviews the known respiratory effects of isocyanates. There is good evidence to indicate that isocyanates: cause chemical bronchitis/pneumonitis; are potent pulmonary sensitisers capable of causing "isocyanate asthma"; cause non-specific airways disease, including chronic bronchitis; can induce a general asthmatic state; and can cause hypersensitivity pneumonitis. Similar dose-response relationships are seen for both acute and chronic effects. There are plants operating in which exposures are well controlled and in which no respiratory effects can be detected. Suggestions are provided for preplacement assessment and periodic surveillance for workers exposed to these compounds.
Descriptors (primary) isocyanates; survey; exposure evaluation; respiratory diseases
Descriptors (secondary) toxic effects; literature survey; threshold limit values; USA; chronic bronchitis; periodic medical examinations; toxic substances; health hazards; dose-response relationship; pneumotoxic effects; toxic asthma
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds
Exposure evaluation