|Document ID (ISN)||52026|
|ISSN - Serial title
||0271-3586 - American Journal of Industrial Medicine
|Convention or series no.
||Musk A.W., Peters J.M., Wegman D.H.
||Isocyanates and respiratory disease: Current status
||1988, Vol.13, No.3, p.331-349. 114 ref.
||This paper reviews the known respiratory effects of isocyanates. There is good evidence to indicate that isocyanates: cause chemical bronchitis/pneumonitis; are potent pulmonary sensitisers capable of causing "isocyanate asthma"; cause non-specific airways disease, including chronic bronchitis; can induce a general asthmatic state; and can cause hypersensitivity pneumonitis. Similar dose-response relationships are seen for both acute and chronic effects. There are plants operating in which exposures are well controlled and in which no respiratory effects can be detected. Suggestions are provided for preplacement assessment and periodic surveillance for workers exposed to these compounds.
||isocyanates; survey; exposure evaluation; respiratory diseases
||toxic effects; literature survey; threshold limit values; USA; chronic bronchitis; periodic medical examinations; toxic substances; health hazards; dose-response relationship; pneumotoxic effects; toxic asthma
||D - Periodical articles
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)