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CISDOC database

Document ID (ISN)51948
CIS number 89-816
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1989
Convention or series no.
Author(s) Vainio H.
Title Carcinogenesis and teratogenesis may have common mechanisms
Bibliographic information Feb. 1989, Vol.15, No.1, p.13-17. Illus. 21 ref.
Abstract The specific mechanisms of carcinogenesis and teratogenesis are poorly understood. There are, however, some known or potential common mechanisms, such as gene or chromosome mutations, interference with gene expression, altered membrane properties, or altered intracellular homeostasis. Carcinogenesis is generally regarded as a multistage process, and a carcinogen can act at one or several stages. Agents acting in the early stages of the neoplastic process are DNA-reactive, mutagenic compounds which enable cells to be transformed to malignancy. These agents can also, if acting during critical periods of ontogenesis, induce abnormal development of the embryo. Agents which block gap junctional intercellular communication may act both as tumour-promoting agents and as teratogens in the developing embryo. Hormones are essential in the control of development and differentiation. Modulation of the intracellular hormone receptors may lead to changes in homeostatis with abnormal cellular proliferation and development as a consequence.
Descriptors (primary) carcinogens; biochemical substances; pathogenesis; teratogenic effects; neoplasms; embryotropic effects
Descriptors (secondary) mutagenic effects; biochemical tests; carcinogenic effects; literature survey
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Genetic factors in reaction to exposures
Antifertility and prenatal effects