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CISDOC database

Document ID (ISN)51830
CIS number 89-851
ISSN - Serial title 0098-7484 - Journal of the American Medical Association
Year 1988
Convention or series no.
Author(s) Blanc P.D., Golden J.A., Gamsu G., Aberle D.R., Gold W.M.
Title Asbestos exposure - Cigarette smoking interactions among shipyard workers
Bibliographic information 15 Jan. 1988, Vol.259, No.3, p.370-373. 36 ref.
Abstract The roentgenograms, pulmonary function tests, and physical findings of 294 shipyard workers were studied with the view to evaluate asbestos exposure-cigarette smoking interactions. Roentgenographic parenchymal opacities, decreased pulmonary diffusing capacity for carbon monoxide, decreased flow at low lung volume, rales, and clubbing were each significantly related to the number of years elapsed since first exposure to asbestos and cigarette smoking status when analysed by logistic regression. A dose-dependent cigarette smoking response that was consistent with synergism was present only for parenchymal opacities and decreased flow at low lung volume. These findings suggest that decreased flow at low lung volume, possibly reflecting peribronchiolar fibrosis, may be a functional corollary to smoking-associated parenchymal roentgenographic opacities among some asbestos-exposed individuals.
Descriptors (primary) carbon monoxide; asbestos; exposure evaluation; shipyards; smoking
Descriptors (secondary) USA; ILO; pulmonary fibrosis; respiratory diseases; opacities; respiratory function tests; dose-response relationship; medical examinations; radiographic testing; toxic substances
Document type D - Periodical articles
Subject(s) Dust, aerosols and related diseases
Broad subject area(s) Chemical safety
Browse category(ies) Smoking
Exposure evaluation
Asbestos
Shipbuliding and ship repair
Carbon monoxide
Inorganic substances