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Document ID (ISN)51720
CIS number 89-920
ISSN - Serial title 0301-0023 - Journal of the Society of Occupational Medicine
Year 1988
Convention or series no.
Author(s) Chattopadhyay P., Karnik A.B., Thakore K.N., Lakkad B.C., Nigam S.K., Kashyap S.K.
Title Health effects among workers involved in the manufacture of hexachlorocyclohexane
Bibliographic information Autumn 1988, Vol.38, No.3, p.77-81. Illus. 17 ref.
Abstract Forty-five male workers exposed to hexachlorocyclohexane (HCH) during its manufacture were studied and compared with 22 matched controls. Twenty-one of the exposed workers worked in packaging and manual transport of HCH. Twenty-four other exposed workers were plant operators. Exposure was mainly through skin. Results indicate that the neurological symptoms reported were due to recent exposure to HCH and were related to the intensity of exposure. An increase in leucine aminopeptidase, ornithine carbamyl transaminase, 5'nucleotides and immunoglobulin M levels among the exposed workers is suggestive of some degree of liver damage. A significant increase in total blood HCH and its α, β and γ isomers was also observed in these workers. In spite of pronounced exposure to the α, β and γ isomers of HCH, signs of severe health impairment were not observed. Further biological monitoring needs to be carried out among such workers exposed to HCH.
Descriptors (primary) agricultural chemicals; hexachlorocyclohexane; agriculture; exposure evaluation; pesticides
Descriptors (secondary) India; packing, filling; hepatotoxic effects; skin absorption; toxic substances; comparative study; neurological effects; chronic poisoning; length of exposure; medical examinations; developing countries; age
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Exposure evaluation
Halogenated hydrocarbons
Agricultural chemicals