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CISDOC database

Document ID (ISN)51659
CIS number 89-853
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Borm P.J.A., Bast A., Zuiderveld O.P.
Title In vitro effect of toluene diisocyanate on beta adrenergic and muscarinic receptor function in lung tissue of the rat
Bibliographic information Jan. 1989, Vol.46, No.1, p.56-59. Illus. 17 ref.
Abstract To investigae the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimulation of metacholine (1ÁM) induced contraction of the tracheal ring by 1ÁM TDI (added in dimethyl sulfoxide). The results were less pronounced when TDI was added from a stock solution prepared in water, which is possibly due to (co)polymerisation. It is concluded that the pharmacological effect of TDI may result from an autonomic imbalance between cholinergic and B-adrenergic neural control.
Descriptors (primary) tolylene diisocyanate; autonomic nervous system; polymerization; respiratory diseases
Descriptors (secondary) lung tissue reaction; in vitro experiments; animal experiments
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds