|Document ID (ISN)||51659|
|ISSN - Serial title
||0007-1072 - British Journal of Industrial Medicine
|Convention or series no.
||Borm P.J.A., Bast A., Zuiderveld O.P.
||In vitro effect of toluene diisocyanate on beta adrenergic and muscarinic receptor function in lung tissue of the rat
||Jan. 1989, Vol.46, No.1, p.56-59. Illus. 17 ref.
||To investigae the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimulation of metacholine (1ÁM) induced contraction of the tracheal ring by 1ÁM TDI (added in dimethyl sulfoxide). The results were less pronounced when TDI was added from a stock solution prepared in water, which is possibly due to (co)polymerisation. It is concluded that the pharmacological effect of TDI may result from an autonomic imbalance between cholinergic and B-adrenergic neural control.
||tolylene diisocyanate; autonomic nervous system; polymerization; respiratory diseases
||lung tissue reaction; in vitro experiments; animal experiments
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the respiratory system (except for pneumoconiosis & similar)