|Document ID (ISN)||51657|
|ISSN - Serial title
||0007-1072 - British Journal of Industrial Medicine
|Convention or series no.
||Nagaya T., Ishikawa N., Hata H.
||Sister chromatid exchange analysis in lymphocytes of workers exposed to hexavalent chromium
||Jan. 1989, Vol.46, No.1, p.48-51. Illus. 24 ref.
||To investigate the usefulness of sister chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers. These results suggest that SCE analysis in human lymphocytes is not a good indicator of possible mutagenic effects of exposure to hexavalent Cr.
||mutagenic effects; lymphocytes; chromium; blood cytology; metal coating
||smoking; comparative study; blood monitoring; exposure tests
||D - Periodical articles
|Broad subject area(s)
Genetic factors in reaction to exposures
Antifertility and prenatal effects