ILO Home
Go to the home page
Site map | Contact us Franšais | Espa˝ol

CISDOC database

Document ID (ISN)51657
CIS number 89-898
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1989
Convention or series no.
Author(s) Nagaya T., Ishikawa N., Hata H.
Title Sister chromatid exchange analysis in lymphocytes of workers exposed to hexavalent chromium
Bibliographic information Jan. 1989, Vol.46, No.1, p.48-51. Illus. 24 ref.
Abstract To investigate the usefulness of sister chromatid exchange (SCE) analysis in lymphocytes as an indicator for mutagenic effects after in vivo exposure to hexavalent chromium (Cr), SCE frequency was analysed in lymphocytes of 44 Cr platers occupationally exposed to hexavalent Cr and 47 controls. Although urinary Cr analysis confirmed that the Cr platers were exposed to Cr, no effects of the exposure on SCE frequency were found. Smokers, both Cr platers and controls, had a significantly higher SCE frequency than non-smokers. These results suggest that SCE analysis in human lymphocytes is not a good indicator of possible mutagenic effects of exposure to hexavalent Cr.
Descriptors (primary) mutagenic effects; lymphocytes; chromium; blood cytology; metal coating
Descriptors (secondary) smoking; comparative study; blood monitoring; exposure tests
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Surface treatment