|Document ID (ISN)||50684|
|ISSN - Serial title
||0018-8247 - Higiena i zdraveopazvane
|Convention or series no.
||Koleva M., Ivanova-Čemišanska L., Burkova T.
||Study on renal function in chronic peroral propineb intoxication
||Proučvane na băbrečnata funkcija pri hronična oralna intoksikacija s propineb [in Bulgarian]|
||1987, Vol.30, No.4, p.34-37. 8 ref.
||Rats were perorally treated with propineb in doses of 425 and 34mg/kg body mass (1/20 and 1/125 LD50), two times weekly for 4.5 months. Renal function was evaluated in terms of: clearance of endogenous creatinine, urea, sodium and potassium, chlorides in serum, serum osmolarity, clearance of free water and percentage of excreted versus filtered sodium. Decreased glomerular filtration and free water clearance, and increased sodium excretion were observed. Morphological studies established that functional changes precede morphological ones, and should be given consideration in the evaluation of pesticide residues in foods and in hygienic standard-setting.
||renal dysfunction; propineb; chronic poisoning; fungicides; dithiocarbamates
||animal experiments; pathomorphology; biochemical tests; renal function tests
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)
||Diseases of the kidney and the urinary system