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Document ID (ISN)50684
CIS number 88-1962
ISSN - Serial title 0018-8247 - Higiena i zdraveopazvane
Year 1987
Convention or series no.
Author(s) Koleva M., Ivanova-Čemišanska L., Burkova T.
Title Study on renal function in chronic peroral propineb intoxication
Original title Proučvane na băbrečnata funkcija pri hronična oralna intoksikacija s propineb [in Bulgarian]
Bibliographic information 1987, Vol.30, No.4, p.34-37. 8 ref.
Abstract Rats were perorally treated with propineb in doses of 425 and 34mg/kg body mass (1/20 and 1/125 LD50), two times weekly for 4.5 months. Renal function was evaluated in terms of: clearance of endogenous creatinine, urea, sodium and potassium, chlorides in serum, serum osmolarity, clearance of free water and percentage of excreted versus filtered sodium. Decreased glomerular filtration and free water clearance, and increased sodium excretion were observed. Morphological studies established that functional changes precede morphological ones, and should be given consideration in the evaluation of pesticide residues in foods and in hygienic standard-setting.
Descriptors (primary) renal dysfunction; propineb; chronic poisoning; fungicides; dithiocarbamates
Descriptors (secondary) animal experiments; pathomorphology; biochemical tests; renal function tests
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Diseases of the kidney and the urinary system