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CISDOC database

Document ID (ISN)50662
CIS number 88-2005
Year 1987
Convention or series no. ECETOC Monograph No.9
Title Assessment of mutagenicity of industrial and plant protection chemicals
Bibliographic information European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, Bte 63, 1050 Bruxelles, Belgium, 1987. 28p. Illus. 29 ref.
Abstract Contents of this report prepared by experts on behalf of ECETOC: general considerations; strategy for the detection of germ cell mutagens; selection of assays and interpretation of test results; tests in-vitro, number and types of tests to employ, genetic specificity of mutagenic action, terminology associated with activity in in-vitro assays, handling of isolated positive responses observed in-vitro, metabolism and tissue distribution; tests in-vivo, the difference between experiments in-vitro and in-vivo, the use of in-vivo somatic cell assays as a pre-sceen for potential germ cell mutagens; correspondence between proposed testing strategy and governmental requirements; recommendations. Regulatory requirements, including suggested tests for the detection of anomalies, are summarised for plant protection chemicals (USA, Netherlands, United Kingdom, Italy and Japan) and for general chemicals (EEC, USA, OECD recommendations).
Descriptors (primary) agricultural chemicals; dangerous substances; mutagenicity tests; hazard evaluation; toxicity evaluation; mutagens
Descriptors (secondary) mutagenic effects; legislation; genetic abnormalities; Netherlands; USA; Japan; Belgium; United Kingdom; European Communities; Italy; pesticides; animal experiments; in vitro experiments; genetic effects; health hazards; carcinogenic effects; carcinogens
Document type E - Books, reports, proceedings
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation
Agricultural chemicals
Genetic factors in reaction to exposures