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CISDOC database

Document ID (ISN)50646
CIS number 88-1957
ISSN - Serial title 0300-581X - Arbeitsmedizin - Sozialmedizin - Prńventivmedizin
Year 1987
Convention or series no.
Author(s) Fruhmann G., Baur X., Vogelmeier C., R÷mmelt H., Pfaller A.
Title Inhalation provocation tests with isocyanates in comparison with methacholine and with skin tests
Original title Inhalative Provokation mit Isocyanaten im Vergleich mit Metacholin und mit dem Hauttest [in German]
Bibliographic information Apr. 1987, Vol.22, No.4, p.94-96. Illus. 2 ref.
Abstract Twenty-nine labourers with suspected isocyanates sensitivity were exposed to isocyanates vapours for up to 2h. After 25 room exposures to toluylene diisocyanates (TDI), a significant rise of the airway resistance measured by whole body plethysmography was found. A comparable elevation was found 6 times after 8 exposures to diphenylmethane diisocyanates (MDI). Eight persons exposed at their place of work already suffered an appreciable bronchial obstruction after at most 1h in TDI or MDI concentrations below the present MAC of 0.01ppm (of these, two persons even at 0.002ppm). 6 persons tested with both TDI and with MDI, 2 reacted only to MDI. Provocation with methacholine gave a "false negative" result for the exposure in 2 of 14 tests, and a "false positive" result in 1 of 6. The intracutaneous skin test produced a response in 6 of 27 exposed persons. Taking the inhalative isocyanates provocation test as a control, the skin test was "false negative" in 3 cases and "false positive" in 1 case. Single exposure for 1-2h to 0.02ppm TDI did not lead to any bronchial obstruction in 15 healthy subjects not exposed occupationally to isocyanates. Among 15 asthmatics, it produced a significant rise in airway resistance in only one third.
Descriptors (primary) isocyanates; allergic respiratory disorders; inhalation tests; allergy tests
Descriptors (secondary) 2,4-tolylene diisocyanate; diphenylmethane diisocyanate
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Diseases of the respiratory system (except for pneumoconiosis & similar)
Cyano compounds