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Document ID (ISN)50640
CIS number 88-1956
ISSN - Serial title 0018-8247 - Higiena i zdraveopazvane
Year 1987
Convention or series no.
Author(s) Ivanova-Čemišanska L., Mirkova E., Mihajlova A., Ilieva P.
Title Studies on acute and subacute oral toxicity of Sandofan C-50
Original title Izsledvane na ostrata i podostrata oralna toksičnost na Sandofan C-50 [in Bulgarian]
Bibliographic information 1987, Vol.30, No.6, p.41-46. Illus. 9 ref.
Abstract Sandofan C-50 is a preparation containing 40% copper oxychloride and 10% oxadixyl. The acute oral LD50 for albino rats (840mg/kg) puts the preparation into group III (moderately hazardous). At doses of 1/20 LD50 (42mg/kg) and 1/50 LD50 (16.8mg/kg) in 30-day experiments, there was no cumulative effect. Moderate signs of general toxic action were seen at the higher dose (42mg/kg): elevated activities of several dehydrogenases in blood and brain tissue, but there was no change in the general physical status and behaviour of the animals. The dose of 16.8mg/kg was inactive under the conditions of the 30-day experiments.
Descriptors (primary) toxic effects; acute poisoning; oxadixyl; copper chloride oxide; fungicides; lethal dose 50; Sandofan C-50
Descriptors (secondary) acute toxicity; cumulative properties; animal experiments; toxicity evaluation
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Halogens and their inorganic compounds
Amides
Inorganic substances