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Document ID (ISN)50630
CIS number 88-2019
ISSN - Serial title 0097-6326 - Federal Register
Year 1986
Convention or series no.
Environmental Protection Agency
Title Guidelines for carcinogenic risk assessment [USA]
Bibliographic information 24 Sep. 1986, Vol.51, No.185, p.33992-34003. 29 ref.
Abstract These guidelines are non-binding policy statements, with no direct effect on the regulated community. It is emphasised that risk assessment is on a case-by-case basis, giving full consideration to all relevant scientific information. Contents: hazard identification (physical and chemical properties, routes and patterns of exposure; structure-activity relationships; metabolic and pharmacokinetic properties; toxicologic effects; short-term, long-term and human tests; weight of the evidence); dose-response assessment, exposure assessment and risk characterisation; the EPA Classification System for categorising weight of evidence for carcinogenicity. Appendices contain responses to comments from outside the Agency on, among other topics: inference guidelines; evaluation of benign tumours; transplacental and multigenerational animal bioassays; maximum tolerated doses; mouse liver tumours; quantitative estimates of risk.
Descriptors (primary) carcinogens; USA; toxicology; carcinogenicity tests; chemical hazards; evaluation of results; hazard evaluation
Descriptors (secondary) benign tumours; routes of entry; exposure evaluation; directive; short-term exposure; long-term exposure; dose-response relationship; animal experiments
Document type F - Information notes, codes of practice, standards
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation