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Document ID (ISN)50627
CIS number 88-2016
ISSN - Serial title 0097-6326 - Federal Register
Year 1986
Convention or series no.
Author(s)
Environmental Protection Agency
Title Guidelines for the health risk assessment of chemical mixtures [USA]
Bibliographic information 24 Sep. 1986, Vol.51, No.185, p.34014-34025. 40 ref.
Abstract These guidelines are non-binding policy documents, with no effect on the regulated community. It is emphasised that risk assessment is on a case-by-case basis, giving consideration to all relevant scientific information. Contents: proposed approach to risk assessment (when data are available on the mixture, when data are available on similar mixtures, and when data are available on mixture components only); assumptions and limitations; mathematical models and the measurement of joint action. Appendices contain responses to comments from outside the Agency on, among other topics: mixtures of carcinogens and systemic toxicants; complex mixtures; dose additivity; interpretation of the Hazard Index; use of interaction data; uncertainties and the sufficiency of the data base.
Descriptors (primary) USA; toxicology; chemical hazards; hazard evaluation; mixtures
Descriptors (secondary) carcinogens; directive; mathematical models; toxic substances
Document type F - Information notes, codes of practice, standards
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Risk evaluation