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CISDOC database

Document ID (ISN)50602
CIS number 88-1974
ISSN - Serial title 0007-1072 - British Journal of Industrial Medicine
Year 1987
Convention or series no.
Author(s) Laplanche A., Clavel F., Contassot J.C., Lanouziere C.
Title Exposure to vinyl chloride monomer: Report on a cohort study
Bibliographic information Oct. 1987, Vol.44, No.10, p.711-715. 21 ref.
Abstract A prospective exposed/non-exposed cohort study was carried out to evaluate the association between mortality and cancer morbidity and occupational exposure to vinyl chloride monomer (VCM). 1,100 VCM exposed subjects and 1,100 VCM non-exposed controls matched for age (▒2yrs), plant, and physician were included and followed up over a 5-year period. The percentages of deaths among the exposed (1.8%) and non-exposed subjects (1.6%) did not differ significantly. 18 (1.6%) and 15 (1.4%) cases of cancer were reported among exposed and non-exposed subjects, respectively. One case of angiosarcoma of the liver and 6 cases of lung cancer occurred among exposed subjects and 2 among non-exposed subjects. The percentage of diseases of the circulatory system was higher (p<0.02) in the 1st than in the 2nd group: this difference was explained mainly by the high incidence of Raynaud's disease (p<0.006).
Descriptors (primary) chemical industry; neoplasms; vinyl chloride
Descriptors (secondary) conditions of exposure; comparative study; France; vinyl polymers; alcoholism; smoking; morbidity; mortality; Raynaud's phenomenon; respiratory diseases; lung cancer; toxic substances; liver cancer; exposure evaluation; long-term study; evaluation of results; health hazards; length of exposure; cardiovascular diseases; circulatory disorders
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Alcohol and drug abuse
Halogenated hydrocarbons
Chemical industry