| Document ID (ISN) | 50602 |
| CIS number |
88-1974 |
| ISSN - Serial title |
0007-1072 - British Journal of Industrial Medicine |
| Year |
1987 |
| Convention or series no. |
|
| Author(s) |
Laplanche A., Clavel F., Contassot J.C., Lanouziere C. |
| Title |
Exposure to vinyl chloride monomer: Report on a cohort study |
| Bibliographic information |
Oct. 1987, Vol.44, No.10, p.711-715. 21 ref. |
| Abstract |
A prospective exposed/non-exposed cohort study was carried out to evaluate the association between mortality and cancer morbidity and occupational exposure to vinyl chloride monomer (VCM). 1,100 VCM exposed subjects and 1,100 VCM non-exposed controls matched for age (±2yrs), plant, and physician were included and followed up over a 5-year period. The percentages of deaths among the exposed (1.8%) and non-exposed subjects (1.6%) did not differ significantly. 18 (1.6%) and 15 (1.4%) cases of cancer were reported among exposed and non-exposed subjects, respectively. One case of angiosarcoma of the liver and 6 cases of lung cancer occurred among exposed subjects and 2 among non-exposed subjects. The percentage of diseases of the circulatory system was higher (p<0.02) in the 1st than in the 2nd group: this difference was explained mainly by the high incidence of Raynaud's disease (p<0.006). |
| Descriptors (primary) |
chemical industry; neoplasms; vinyl chloride |
| Descriptors (secondary) |
conditions of exposure; comparative study; France; vinyl polymers; alcoholism; smoking; morbidity; mortality; Raynaud's phenomenon; respiratory diseases; lung cancer; toxic substances; liver cancer; exposure evaluation; long-term study; evaluation of results; health hazards; length of exposure; cardiovascular diseases; circulatory disorders |
| Document type |
D - Periodical articles |
| Subject(s) |
Occupational pathology
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Chemical industry
Alcohol and drug abuse
Halogenated hydrocarbons
|
