|Document ID (ISN)||50209|
|ISSN - Serial title
||0096-1736 - Journal of Occupational Medicine
|Convention or series no.
||Arfini G., Mutti A., Vescovi P., Ferroni C., Ferrari M., Giaroli C., Passeri M., Franchini I.
||Impaired dopaminergic modulation of pituitary secretion in workers occupationally exposed to styrene: Further evidence from PRL response to TRH stimulation
||Oct. 1987, Vol.29, No.10, p.826-830. Illus. 19 ref.
||The prolactin (PRL) response to thyrotrophin-releasing hormone (TRH) was measured in 16 female workers exposed to styrene and in 16 sex- and age-matched controls with the aim of evaluating whether tubero-infundibular dopaminergic activity is impaired by styrene exposure. Only 1 exposed worker compared with 15 controls showed a normal response to TRH. In styrene workers, the median values of PRL in serum samples taken 10, 20, 30 and 45min after TRH administration were higher than the upper reference limit showing a threshold increase compared with the control values. The peak PRL level correlated with the urinary excretion of styrene metabolites. In 2 women who had changed work, the PRL response to TRH was normal after they had been removed from exposure for 2 months. These findings suggest that styrene exposure impairs the dopaminergic modulation of pituitary secretion. Such an effect might explain subjective symptoms and behavioural disturbances that are often recorded among styrene exposed workers.
||styrene; pituitary disorders; hazard evaluation; hormone secretion; dopamine excretion
||biochemical effects; urinary metabolites
||D - Periodical articles
||Toxic and dangerous substances
|Broad subject area(s)