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CISDOC database

Document ID (ISN)50209
CIS number 88-1263
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1987
Convention or series no.
Author(s) Arfini G., Mutti A., Vescovi P., Ferroni C., Ferrari M., Giaroli C., Passeri M., Franchini I.
Title Impaired dopaminergic modulation of pituitary secretion in workers occupationally exposed to styrene: Further evidence from PRL response to TRH stimulation
Bibliographic information Oct. 1987, Vol.29, No.10, p.826-830. Illus. 19 ref.
Abstract The prolactin (PRL) response to thyrotrophin-releasing hormone (TRH) was measured in 16 female workers exposed to styrene and in 16 sex- and age-matched controls with the aim of evaluating whether tubero-infundibular dopaminergic activity is impaired by styrene exposure. Only 1 exposed worker compared with 15 controls showed a normal response to TRH. In styrene workers, the median values of PRL in serum samples taken 10, 20, 30 and 45min after TRH administration were higher than the upper reference limit showing a threshold increase compared with the control values. The peak PRL level correlated with the urinary excretion of styrene metabolites. In 2 women who had changed work, the PRL response to TRH was normal after they had been removed from exposure for 2 months. These findings suggest that styrene exposure impairs the dopaminergic modulation of pituitary secretion. Such an effect might explain subjective symptoms and behavioural disturbances that are often recorded among styrene exposed workers.
Descriptors (primary) styrene; pituitary disorders; hazard evaluation; hormone secretion; dopamine excretion
Descriptors (secondary) biochemical effects; urinary metabolites
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Endocrine diseases
Aromatic hydrocarbons
Risk evaluation