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CISDOC database

Document ID (ISN)50051
CIS number 88-1180
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1987
Convention or series no.
Author(s) Selevan S.G., Lemasters G.K.
Title The dose-response fallacy in human reproductive studies of toxic exposures
Bibliographic information May 1987, Vol.29, No.5, p.451-454. Illus. 13 ref.
Abstract The manner in which exposure is defined can affect the findings of reproductive studies of toxic exposures. The individual end points potentially examined, such as foetal loss, subfertility, and congenital malformations are effects of different severity. The most extreme effect of the 3 is infertility because no pregnancy is possible, and the least extreme, congenital malformations recognised at birth. End points observed at birth are survivors of a long and complex process. The process yielding one of these adverse end points may result from a number of factors, of which exposure is only one. For example, a very high exposure could result in early foetal loss, whereas a lower one might result in a congenital malformation observed at birth. If the probability of a less severe end point falls due to increasing probability of more severe end points with increasing exposure, then a contradictional dose-response relationship may be observed in the study of one type of outcome.
Descriptors (primary) antifertility effects; expectant mothers; sterility; toxic substances
Descriptors (secondary) genetic abnormalities; evaluation of technique; epidemiologic study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the reproductive system
Genetic factors in reaction to exposures
Antifertility and prenatal effects