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Document ID (ISN)50043
CIS number 88-1243
ISSN - Serial title Gigiena truda i professional'nye zabolevanija
Year 1986
Convention or series no.
Author(s) Molodkina N.N., Fomenko V.N., Sal'nikova L.S., Domšlak M.G., Kotosova L.D., Matveev A.A., Voroncov R.S., Gluščenko V.I., Silant'eva I.V., Pavlenko G.I.
Title Bases for a MAC for dimethyl sulfate in workplace air
Original title Materialy k obosnovaniju predel'no dopustimyh koncentracij dimetilsulfata v vozduhe rabočej zony [in Russian]
Bibliographic information Sep. 1986, No.9, p.38-41. Illus. 7 ref.
Abstract Dimethyl sulfate (DMS) was administered to animals by inhalation in single, repeated and chronic doses. DMS may induce acute (lethal or nonlethal) or chronic poisoning; it shows marked irritating action and penetrates the skin. It is also embryotopic, mutagenic and blastomagenic. The most sensitive indicator of DMS toxicity is its cytogenic effect, as at the lowest concentration tried (0.3µg/m3) a cytogenic effect was manifested in the frequency of chromosome abberation in bone marrow cells. The recommended MAC for DMS in workplace air is 0.1mg/m3 with note "dangerous: skin penetration" hazard class 1, state aggregation-vapour.
Descriptors (primary) mutagenic effects; threshold limit values; USSR; embryotropic effects; dimethyl sulfate; chronic poisoning; inhalation toxicity; determination in air; cytotoxic effects
Descriptors (secondary) toxic effects; animal experiments; toxic substances; dangerous substances
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Esters and salts
Genetic factors in reaction to exposures
Occupational exposure limits