| Document ID (ISN) | 50043 |
| CIS number |
88-1243 |
| ISSN - Serial title |
Gigiena truda i professional'nye zabolevanija |
| Year |
1986 |
| Convention or series no. |
|
| Author(s) |
Molodkina N.N., Fomenko V.N., Sal'nikova L.S., Domšlak M.G., Kotosova L.D., Matveev A.A., Voroncov R.S., Gluščenko V.I., Silant'eva I.V., Pavlenko G.I. |
| Title |
Bases for a MAC for dimethyl sulfate in workplace air |
| Original title |
Materialy k obosnovaniju predel'no dopustimyh koncentracij dimetilsulfata v vozduhe rabočej zony [in Russian] |
| Bibliographic information |
Sep. 1986, No.9, p.38-41. Illus. 7 ref. |
| Abstract |
Dimethyl sulfate (DMS) was administered to animals by inhalation in single, repeated and chronic doses. DMS may induce acute (lethal or nonlethal) or chronic poisoning; it shows marked irritating action and penetrates the skin. It is also embryotopic, mutagenic and blastomagenic. The most sensitive indicator of DMS toxicity is its cytogenic effect, as at the lowest concentration tried (0.3µg/m3) a cytogenic effect was manifested in the frequency of chromosome abberation in bone marrow cells. The recommended MAC for DMS in workplace air is 0.1mg/m3 with note "dangerous: skin penetration" hazard class 1, state aggregation-vapour. |
| Descriptors (primary) |
mutagenic effects; threshold limit values; USSR; embryotropic effects; dimethyl sulfate; chronic poisoning; inhalation toxicity; determination in air; cytotoxic effects |
| Descriptors (secondary) |
toxic effects; animal experiments; toxic substances; dangerous substances |
| Document type |
D - Periodical articles |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Esters and salts
Genetic factors in reaction to exposures
Occupational exposure limits
Antifertility and prenatal effects
|
