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Document ID (ISN)49987
CIS number 88-1174
ISSN - Serial title 0355-3140 - Scandinavian Journal of Work, Environment and Health
Year 1987
Convention or series no.
Author(s) Thomas T.L., Stewart P.A., Stemhagen A., Correa P., Norman S.A., Bleecker M.L., Hoover R.N.
Title Risk of astrocytic brain tumors associated with occupational chemical exposures
Bibliographic information Oct. 1987, Vol.13, No.5, p.417-423. 29 ref.
Abstract A case-referent study was conducted on the risk of brain tumours among workers exposed to organic chemicals in petroleum refining and chemical manufacturing. The cases (N = 300) were white men aged ≥ 30 years with a confirmed diagnosis of glioblastoma multiforme, astrocytoma, or a mixed glioma with astrocytic cells. The referents (N = 386) were white men who died from causes other than brain tumour, epilepsy, cerebrovascular disease, suicide, or homicide and were frequency-matched with the cases on age at death, year of death, and study area. No statistically significantly elevated odds ratios were associated with employment in the chemical industry. The risk of astrocytic tumours was elevated among the subjects with production or maintenance jobs in petroleum refining; however, it decreased with length of employment. There were nonsignificant excess risks of astrocytic tumours among the men exposed to cutting fluids or organic solvents and also among the subjects exposed to lubricating oils, organic solvents, or cutting fluids for ≥ 20 years.
Descriptors (primary) chemical industry; brain cancer; petroleum refining; chemical products; hazard evaluation; toxic substances
Descriptors (secondary) case study; mortality; statistical aspects; cutting fluids; organic solvents; lubricating oils
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Diseases of the nervous system
Risk evaluation
Petrochemical industry
Chemical industry
Petroleum and natural gas industry