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Document ID (ISN)49934
CIS number 88-1223
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 1987
Convention or series no.
Author(s) Sarto F., Clonfero E., Bartolucci G.B., Franceschi C., Chiricolo M., Levis A.G.
Title Sister chromatid exchanges and DNA repair capability in sanitary workers exposed to ethylene oxide: Evaluation of the dose-effect relationship
Bibliographic information 1987, Vol.12, No.5, p.625-637. Illus. 30 ref.
Abstract Determination of ethylene oxide (EtO) in the working environment and induction of sister chromatid exchanges (SCE) and unscheduled DNA synthesis (UDS) in peripheral lymphocytes of 10 exposed workers and 10 control subjects matched for sex, age, and smoking habits are reported. The 10 newly examined workers were exposed to EtO concentrations (1.84ppm as time-weighted average) intermediate between the high (10.7ppm) and low (0.35ppm) levels of exposure of the two previously examined groups (19 and 22 workers, respectively). A statistically significant increase of SCE frequency was observed between the present control and exposed groups. The inducibility of UDS by gamma rays was insignificantly lower in the lymphocytes of the exposed workers than in controls. A significant relation between the frequency of SCE and the level of EtO exposure for the three exposed groups was demonstrated by two statistical methods. It is suggested that the present Italian threshold limit value for EtO (3ppm) may not protect the exposed workers against possible genotoxic effects and that even a chronic exposure to 1ppm may not be devoid of genotoxic risk.
Descriptors (primary) disinfection of equipment; DNA; dose-response relationship; hospitals; chromosome changes; ethylene oxide
Descriptors (secondary) exposure evaluation; mutagenic effects
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Genetic factors in reaction to exposures
Ethers
Ethylene oxide
Health care services