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Document ID (ISN)49137
CIS number 88-245
ISSN - Serial title 0236-607X - Munkavédelem, munka- és üzemegészségügy
Year 1986
Convention or series no.
Author(s) Ungváry G.
Title Embryotoxic and teratogenic effects of benzene and alkylbenzene compounds
Original title A benzol és alkil-származékainak embriotoxikus és teratogén hatása [in Hungarian]
Bibliographic information 1986, Vol.32, No.7-9, p.146-166. Illus. 86 ref.
Abstract Animal experiments involving female rats, mice and rabbits at or about the time they become pregnant. Exposure was by inhalation of different concentrations of benzene, toluene, o-, m-, p- and mixed xylenes, ethylbenzene, aromatol (a mixture of aromatic hydrocarbons) and clean air. On the whole, at a high enough exposure level, growth retardation or death of the foetus was noted, but teratogenic effects were found only for ethylbenzene and aromatol. Abortion was induced mostly in rabbits. A method is described for the determination of exposure levels and times at which no embryotoxic or teratogenic effects are found.
Descriptors (primary) embryotoxic effects; hydrocarbons; teratogenic effects; benzene; aromatic hydrocarbons
Descriptors (secondary) toluene; ethylbenzene; p-xylene; abortion; xylene; description of technique; o-xylene; animal experiments; determination of exposure limits; length of exposure; m-xylene
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Antifertility and prenatal effects
Aromatic hydrocarbons
Genetic factors in reaction to exposures