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Document ID (ISN)48965
CIS number 88-248
ISSN - Serial title 0096-1736 - Journal of Occupational Medicine
Year 1987
Convention or series no.
Author(s) Lockey J.D., Kelly C.R., Cannon G.W., Colby T.V., Aldrich V., Livingston G.K.
Title Progressive systemic sclerosis associated with exposure to trichloroethylene
Bibliographic information June 1987, Vol.29, No.6, p.493-496. Illus. 26 ref.
Abstract Although neither the aetiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of solvents. An example is given of a 47-year old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux oesophagitis, microangiopathic haemolytic anaemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis.
Descriptors (primary) scleroderma; organic solvents; trichloroethylene
Descriptors (secondary) case study
Document type D - Periodical articles
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Skin diseases