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CISDOC database
Document ID (ISN) | 48965 |
CIS number |
88-248 |
ISSN - Serial title |
0096-1736 - Journal of Occupational Medicine |
Year |
1987 |
Convention or series no. |
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Author(s) |
Lockey J.D., Kelly C.R., Cannon G.W., Colby T.V., Aldrich V., Livingston G.K. |
Title |
Progressive systemic sclerosis associated with exposure to trichloroethylene |
Bibliographic information |
June 1987, Vol.29, No.6, p.493-496. Illus. 26 ref. |
Abstract |
Although neither the aetiology nor pathogenesis of progressive systemic sclerosis (scleroderma) has been established, this disease has been associated with a wide variety of solvents. An example is given of a 47-year old woman with previous excellent health who developed fatal progressive systemic sclerosis after a single 2.5-hour predominantly dermal exposure to trichloroethylene. During a period of 10 months the patient developed proximal scleroderma, reflux oesophagitis, microangiopathic haemolytic anaemia, restrictive pulmonary disease, pericarditis with effusion, and renal insufficiency with severe hypertension. Renal and skin biopsies were consistent with progressive systemic sclerosis. |
Descriptors (primary) |
scleroderma; organic solvents; trichloroethylene |
Descriptors (secondary) |
case study |
Document type |
D - Periodical articles |
Subject(s) |
Occupational pathology
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Broad subject area(s) |
Chemical safety
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Browse category(ies) |
Halogenated hydrocarbons Skin diseases
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