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Document ID (ISN)48941
CIS number 88-254
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1986
Convention or series no.
Author(s) Žmin'ko P.G.
Title Characteristics of the toxic action of cyclofos under conditions of continuous and intermittent exposure
Original title Osobennosti toksičeskogo dejstvija ciklofosa v uslovijah monotonnogo i intermittirujuščego vozdejstvija [in Russian]
Bibliographic information Aug. 1986, No.8, p.42-44. Illus. 4 ref.
Abstract Continuous intratracheal administration of cyclofos caused a more pronounced toxic effect than intermittent administration did. Inhibition of the monooxygenase enzyme system of the liver and lungs was observed on continuous exposure, and induction of this system with more evident changes in lungs on intermittent exposure. The results were used as a basis for a MAC for cyclofos in workplace air for agriculture of 0.5mg/m3 (vapour + aerosol), with indication "penetrates through skin; hazard class 2".
Descriptors (primary) threshold limit values; USSR; hepatotoxic effects; cyclofos; pneumotoxic effects; insecticides; toxicology; toxic hepatitis; pesticides
Descriptors (secondary) animal experiments; enzyme inhibition
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Occupational exposure limits
Liver diseases
Esters and salts