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Document ID (ISN)48897
CIS number 88-233
ISSN - Serial title 0047-1879 - Japanese Journal of Industrial Health - Sangyō-Igaku
Year 1987
Convention or series no.
Author(s) Kawai A., Goto S., Matsumoto Y., Matsushita H.
Title Mutagenicity of aliphatic and aromatic nitro compounds - Industrial materials and related compounds
Original title Shibōzoku oyobi hōkōzoku nitoru kag˘butsu no hen'i gensei. Kōgyō zairyō oyobi sono kanren busshitsu [in Japanese]
Bibliographic information Jan. 1987, Vol. 29, No.1, p.34-54. Illus. 27 ref.
Abstract The mutagenicity of 102 aliphatic and aromatic nitro compounds, industrial materials and related chemicals was tested with Salmonella typhimurium and Escherichia coli. Four out of 8 aliphatic nitro compounds and 61 out of 94 nitrobenzene derivatives were mutagenic. Fifteen chemicals produced more than 10,000 revertants/mg: tetranitromethane, chloropicrin, 1,3,5-trinitrobenzene, 2,4-dinitroflurobenzene, p-nitrobenzyl chloride, 3,5-dinitrobenzyl chloride, p-nitrophenylhydrazine, 2,4-dinitrophenylhydrazine, 2,4-dinitrophenylthiocyanate and nitramine. Nitrobenzene was not mutagenic, but many mono-substituted nitrobenzenes were. The mutagenicity of dinitrobenzene was enhanced by an -F, -SCN, -NH2, -Cl, -CH2Cl, -NO2, -NH-NH2 or -COCl group, and suppressed by -COOH or -CH3. Twenty-three out of 45 chemicals for which exposure limits have been established in many countries in the world were mutagenic. Three carcinogens, 2-nitropropane, 2,4-dinitrotoluene and 2,6-dinitrotoluene, were all mutagenic, but their mutagenic activity was weak. Many chemicals were found to have a stronger mutagenic activity and a chemical structure similar to the carcinogenic dinitrotoluenes. This fact suggests the necessity of testing the carcinogenicity of these chemicals.
Descriptors (primary) 2-bromo-4,6-dinitroaniline; aromatic nitro compounds; p-nitrophenylhydrazine; nitramine; tetranitromethane; 1-(chloromethyl)-4-nitrobenzene; 1,3,5-trinitrobenzene; 3,5-dinitrobenzyl chloride; 3,5-dinitroaniline; fluorodinitrobenzene; 2,3-dinitrophenol; 2,4-dinitrophenyl thiocyanate; 1-chloro-2,4-dinitrobenzene; chloropicrin; 2,6-dinitroaniline; 2,4-dinitrophenylhydrazine; aliphatic nitro hydrocarbons; mutagens
Descriptors (secondary) mutagenicity tests
Document type D - Periodical articles
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Aliphatic nitro compounds
Cyano compounds