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Document ID (ISN)48882
CIS number 88-206
ISSN - Serial title 0003-4878 - Annals of Occupational Hygiene
Year 1986
Convention or series no.
Author(s) Seniori Costantini A., Paci E., Scala D., Cariaggi P., Cipparrone G., Confortini M., Maddau C., Butt R., Dolara P., Salvadori M., Caderni G.
Title Monitoring of carcinogenic risks in tannery workers by means of desquamative lung and bladder cytology and urinary mutagenicity
Bibliographic information 1986, Vol.31, No.1, p.21-30. Illus. 18 ref.
Abstract Proportional mortality data on a cohort of tannery workers showed an increased risk of lung cancer, oesophageal cancer, sarcomas and leukaemias. From a cohort of workers and controls in the same area, data were obtained on urinary mutagenic activity using Salmonella typhimurium TA1538 and TA100 as tester strains, with and without metabolic activation. The mutagenic activity of the urine of tanning workers did not differ from that of clerical workers. Bladder desquamative cytology did not show any difference between clerical controls and workers. Pulmonary cytology specimens were normal or showed cellular atypical metaplasia. No cases with atypical cells or obvious neoplastic changes were found. The relative risk of pathological lung cytology was higher in chemical refining than in mechanical refining and tanning.
Descriptors (primary) mutagenic effects; carcinogens; lung cancer; sputum cytology; tanning industry; urine cytology; exposure evaluation
Descriptors (secondary) epidemiologic study; mortality
Document type D - Periodical articles
Subject(s) Leather, fur and footwear
Broad subject area(s) Industries and occupations
Browse category(ies) Antifertility and prenatal effects
Diseases of the respiratory system (except for pneumoconiosis & similar)
Footwear, leather and fur industry
Genetic factors in reaction to exposures
Exposure evaluation