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Document ID (ISN)48857
CIS number 88-252
ISSN - Serial title 0016-9900 - Gigiena i sanitarija
Year 1986
Convention or series no.
Author(s) Ščickova A.P., Nikolaeva N.I., Gadolina I.D.
Title Hygienic assessment of the cardiotoxic action of some pesticides
Original title Gigieničeskaja ocenka kardiotoksičeskogo dejstvija nekotoryh pesticidov [in Russian]
Bibliographic information June 1986, No.6, p.4-7. Illus.
Abstract The cardiovascular system in rats (mature animals and embryos) exposed to pesticides (acetochlor, dianat, isophos-3, sumilex) was studied. A complex of cytomorphological, histochemical, biochemical and electrophysiological methods was used in the study. All the above-mentioned chemicals administered in high doses produced stereotypic heterogeneous disorders of cell structure and function, as well as vascular and microcirculatory disturbances. Lesions in the elements of the cardiovascular system depend on concentration and duration of exposure: effects were more evident in rats exposed to dianat and acetochlor, less evident in those exposed to isophos-3 and sumilex. Administration of low doses of pesticides revealed some features of their biological action on the elements of the cardiovascular system that dependend on the chemical structure of the individual compounds. Cardio-bioelectric activity in rats at different stages of ontogenesis was studied. The pesticides showed an ability to cross the placenta and affect the foetus.
Descriptors (primary) hazard criteria; pesticides; cardiotoxic effects; cardiovascular disorders; exposure evaluation; transplacental absorption
Descriptors (secondary) Dicamba; sumilex; isophos-3; animal experiments; dose-response relationship; acetochlor
Document type D - Periodical articles
Subject(s) Agriculture, fishing, animal husbandry
Broad subject area(s) Chemical safety
Browse category(ies) Agricultural chemicals
Exposure evaluation
Cardiovascular diseases